Last edited by Narr
Monday, July 20, 2020 | History

3 edition of Antimicrobial agents and intracellular pathogens found in the catalog.

Antimicrobial agents and intracellular pathogens

  • 346 Want to read
  • 38 Currently reading

Published by CRC Press in Boca Raton, FL .
Written in English

    Subjects:
  • Anti-infective agents -- Bioavailability.,
  • Intracellular pathogens.,
  • Antibiotics -- therapeutic use.,
  • Anti-Infective Agents -- therapeutic use.,
  • Immunity, Cellular.,
  • Infection -- drug therapy.

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by Didier Raoult.
    ContributionsRaoult, Didier.
    Classifications
    LC ClassificationsRM409 .A59 1993
    The Physical Object
    Pagination378 p. :
    Number of Pages378
    ID Numbers
    Open LibraryOL1395349M
    ISBN 100849349249
    LC Control Number93002668

    ANTIMICROBIAL AGENTS:CLASSIFICATION & MOA INHIBITION OF BACTERIAL CELL WALL SYNTHESIS Gm.+ve wall contains peptidoglycan & techoic acid & may /maynot be surrounded by a protein polysacch envelope. Gm –ve wall contains peptidoglycan, and an outer. The Gram negative outer membrane can act as an efficient intrinsic permeability barrier to the egress of certain antimicrobial agents such as vancomycin. 79 In addition, surface charge modification, as indicated here, is a well-established mechanism of resistance to cationic antimicrobial peptides, such as the action of the ArnB enzyme on LPS.

      An in-depth review of one of the most important classes of antimicrobial agents discovered in recent years. • Includes information on the treatment of intra-abdominal infections and infections caused by intracellular pathogens and the use of fluoroquinolones in intensive care unit infections and in pediatrics. • Covers adverse effects.   The human milk protein-lipid complex HAMLET sensitizes bacterial pathogens to traditional antimicrobial agents. PloS one 7, e, / ().

    antibiotics. A classic example of intrinsic resistance is the antimicrobial resistance conferred by the chromosomally encoded marRAB locus of Escherichia coli [10]. This genetic element is responsible for the J o u r n a l o f A n t im cro b i a A g e n t s ISSN: Journal of Antimicrobial Agents Rao et al., J Antimicrob Agents , The antimicrobial actions of these agents are a result of differences in prokaryotic and eukaryotic enzymes involved in nucleic acid synthesis. Prokaryotic transcription is the process in which messenger RNA transcripts of genetic material are produced for later translation into proteins.


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Antimicrobial agents and intracellular pathogens Download PDF EPUB FB2

Antimicrobial Agents and Intracellular Pathogens is the first book devoted to the relationships among intracellular pathogens, antibiotics, and cells. The book is divided into two sections. Part One describes the effects of antibiotics on uninfected and infected phagocytic cells, the subcellular location of antibiotic compounds, the subcellular Cited by: Description: Antimicrobial Agents and Intracellular Pathogens is the first book devoted to the relationships among intracellular pathogens, antibiotics, and cells.

The book. Summary: Divided into two sections this book begins with the effects of antibiotics on uninfected and infected phagocytic cells. Part Two focuses on intracellular pathogens used as paradigms, including strict intracellular bacteria and antibiotics such as Chlamydia and Coxeilla Burnetii.

Our goal here was to discover drugs that perturb host cell targets and limit infection by intracellular pathogens. We refer to such agents as “host-directed antimicrobial drugs,” or HDADs.

Such agents may have the additional benefit of reducing the Cited by: Antimicrobial packaging is a fast emerging area in food packaging. Antimicrobial agents can be incorporated into polymeric food packaging materials to enhance the shelf-life of packaged foods, by preserving the foods against microbial spoilage and hazardous food-borne microorganisms.

This chapter reviews different classes of antimicrobials. Intracellular pathogens Antimicrobial susceptibility testing is crucial to guide effective treatment against obligate intracellular bacteria and to understand therapeutic successes and failures.

Intracellular localization of infectious agents such as bacteria protects antimicrobial agents from the host immune system, but also from the action of antimicrobial agents. Infectious agents localized in phagocytic cells can use antimicrobial agents as a “Trojan horse” to induce secondary site infection and hence lead to recurrent infections.

About this book The global spread of antimicrobial-resistant pathogenic bacteria is a continuing challenge to the health care of humans and domesticated animals. With no new agents on the horizon, it is imperative to use antimicrobial agents wisely to preserve their.

Infections with intracellular bacterial pathogens are hard to treat due to the inability of conventional antimicrobial agents to penetrate, accumulate, or be retained in the mammalian cells [ 1 ]. The increasing problem of antibiotic resistance complicates more the treatment of the diseases caused by these agents.

In the face of increasing rates of antimicrobial resistance in complicated urinary tract infections (cUTIs), clinicians need to understand cross-resistance patterns among commonly encountered pathogens.

We performed a multicenter, retrospective cohort study in the Premier database of approximately hospitals, from to This chapter gives an overview of intracellular pathogens, problems in the eradication of intracellular infection, and different nanocarrier systems being used to deliver antimicrobial agents for.

While antimicrobial peptides (AMPs) are well-known for their disruptive effects on bacterial membranes, the mechanism of many intracellular AMPs is still being elucidated.

In the recent years, it has been demonstrated that the subclass of proline-rich AMPs (PrAMPs) can pass through the bacterial membrane and kill bacteria by inhibiting protein. Antimicrobial Resistance in Chlamydiales, Rickettsia, Coxiella, and Other Intracellular Pathogens, p In Schwarz S, Cavaco L, Shen J (ed), Antimicrobial Resistance in Bacteria from Livestock and Companion Animals.

ASM Press, Washington, DC. doi: / Antimicrobial peptides (AMPs), also called host defense peptides (HDPs) are part of the innate immune response found among all classes of life. Fundamental differences exist between prokaryotic and eukaryotic cells that may represent targets for antimicrobial peptides are potent, broad spectrum antibiotics which demonstrate potential as novel therapeutic agents.

Bacteria that cause bacterial infections and disease are called pathogenic bacteria. They cause diseases and infections when they get into the body and begin to reproduce and crowd out healthy bacteria or to grow into tissues that are normally sterile.

To cure infectious diseases, researchers discovered antibacterial agents, which are considered to be the most promising chemotherapeutic agents. In book: Antimicrobial Agents and Intracellular Pathogens, Chapter: Chap Publisher: CRC Press Inc., Boca Raton, USA, Editors: Didier Raoult, pp Considering specific parameters.

In fact, NP-antimicrobial agents are able to unlock the restrictions experienced by conventional antimicrobial agents. This review discusses the status quo of NP-antimicrobial agents as potent broad spectrum antimicrobial agents, sterilization and wound healing agents, and sustained inhibitors of intracellular pathogens.

Rhodococcus equi is a facultative intracellular pathogen that causes infections in foals and many other animals such as pigs, cattle, sheep, and goats.

Antibiotic resistance is rapidly rising in horse farms, which makes ineffective current antibiotic treatments based on a combination of macrolides and rifampicin.

Therefore, new therapeutic strategies are urgently needed to treat R. equi. The chronic infections related to biofilm and intracellular bacteria are always hard to be cured because of their inherent resistance to both antimicrobial agents and host defenses.

Herein we. The book details the scientific knowledge about how these obligate intracellular bacteria invade, survive and replicate inside eukaryotic cells and also describes the spectrum of disease caused by an infection including protective and pathologic immune responses.

Antimicrobial Drug Resistance The introduction of an antibiotic into the microbial environment is a selective factor that over time can select for resistant pathogens. The main ways to minimize this problem are: 1) administer the antibiotic at the prescribed dose for the prescribed duration 2) use antibiotics in combination.

Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with .Antimicrobial agent, any of a large variety of chemical compounds and physical agents that are used to destroy microorganisms or to prevent their development.

The production and use of the antibiotic penicillin in the early s became the basis for the era of modern antimicrobial therapy.